Crossword Dictionary

ire

anger, choler, ire - n 
a strong emotion; a feeling that is oriented toward some real or supposed grievance 

wordplays

synonyms

anger, angriness, birse [chiefly Scottish], choler, furor, fury, indignation, irateness, lividity, lividness, mad, madness, mood [archaic], outrage, rage, spleen, wrath, wrathfulness

in a sentence

He directed his ire at the coworkers who reported the incident. 

the patronizing comment from the snooty waiter roused her ire

merriam-webster

etymology

c. 1300, from Old French ire "anger, wrath, violence" (11c.), from Latin ira "anger, wrath, rage, passion," from PIE root *eis- (1), forming various words denoting passion (source also of Greek hieros "filled with the divine, holy," oistros "gadfly," originally "thing causing madness;" Sanskrit esati "drives on," yasati "boils;" Avestan aesma "anger;" Lithuanian aistra "violent passion").

Old English irre in a similar sense is unrelated; it is from an adjective irre "wandering, straying, angry," which is cognate with Old Saxon irri "angry," Old High German irri "wandering, deranged," also "angry;" Gothic airzeis "astray," and Latin errare "wander, go astray, angry" (see err (v.)).

etymonline